Advantages of Using 96 Tomtec SPE Tips over 96-Well SPE Plate

1. Independent SPE for each tip (concurrent 96 mini SPE columns)

2. Positive pressure liquid flow for tips vs. negative pressure vacuum flow for 96-well SPE plate
   • Less variable results
   • Higher recovery and loading capacity due to recirculation
   • Better liquid flow control of critical loading and elution steps
   • No differential vacuum treatment
   • No need to cover unused wells
   • Easy to expand to 384 SPE

3. Less expensive to operate
   • No waste of unused SPE wells
   • Low consumption of solvents, reagents, and tips
   • Low solvent disposal
   • No need to use vacuum manifold, in-house vacuum, and centrifuge

4. Low cross-well contamination and carry-over
   • Liquid flow is confined inside tips and collection plate vs. close proximity between well-to-well in SPE plate

5. Very short run time per assay
   • Fewer operational steps
   • Continuous SPE operation

6. Easy detection and possible recovery of clogged samples
   • Easy and clear to observe each tip's SPE process

7. Great for animal samples with low volume
   • Elution with low volume ready for injection (elute and shot technique)

8. Fast method development
   • Use Combination of different packings on a tip rack for quick method development